| Biography: | Professor Graham Lieschke is a clinical and research haematologist. He is internationally recognised for his research into blood disorders and cancer using zebrafish and mice. He is also a clinical haematologist at the Royal Melbourne Hospital, where he treats people with leukaemia and lymphoma.
Prof Lieschke received his medical science and medical degrees from the University of Melbourne in 1983. He undertook his specialist clinical training in medical oncology at the Royal Melbourne Hospital (RMH), obtaining his FRACP in 1991. His undergraduate laboratory and clinical research cultivated his interest in haematology, and as the first Ludwig Institute/RMH Clinical Fellow, he was part of the team that introduced the white blood cell growth factors into clinical practice. In his PhD project at the Ludwig Institute for Cancer Research (Melbourne Branch), he undertook one of Australia’s first gene knockout projects, proving that G-CSF was a key physiological regulator of granulocyte production. His postdoctoral training was at the Whitehead Institute in Cambridge, Massachusetts, USA, in tumour immunology. He returned to Australia in 1997 as an independent investigator. He established his zebrafish-based research program while at the Ludwig Institute for Cancer Research, and continued this as a Laboratory Head in the Cancer and Haematology Division of the Walter and Eliza Hall Institute. His work seeks to exploit the unique strengths of the zebrafish model in genetics, embryology, and for visualizing cell behaviour in vivo to understand blood cell development and diseases. His awards include: the John Maynard Hedstrom Research Fellowship of the Cancer Council of Victoria, a Howard Hughes Postdoctoral Research Fellowship for Physicians, a Wellcome Trust Senior Research Fellowship, and currently, an NHMRC Senior Research Fellowship. The Ludwig Institute awarded him its inaugural George Hodgson Medal for Medical Science. He has published 89 scientific papers and co-edited 2 books. Prof . Lieschke is also passionate about the organ and choral music of J.S. Bach, an interest for which he was awarded the Dame Roma Mitchell Churchill Fellowship.
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| Selected Publications: | Papers
Lieschke GJ, Oates AC, Crowhurst MO, Ward AC, Layton JE. Morphological
and functional characterization of granulocytes and macrophages in
embryonic and adult zebrafish. Blood, 98(10);3087-3096,
2001.
Lieschke GJ, Oates AC, Paw BH, Thompson MA, Hall NE, Ward AC, Ho
RK, Zon LI, Layton JE. Zebrafish SPI-1 (PU.1) marks a site of
myeloid development independent of primitive erythropoiesis;
implications for axial patterning. Developmental Biology,
246(2):274-295, 2002.
Hogan BM, Hunter MP, Oates AC, Crowhurst MO, Hall NE, Heath JK, Prince
VE, Lieschke GJ. Zebrafish gcm2 is required for gill filament
budding from pharyngeal ectoderm. Developmental Biology,
276(2):508-522, 2004.
Hogan BM, Layton JE, Pyati UJ, Nutt SL, Hayman JW, Varma S, Heath JK,
Kimelman D, Lieschke GJ. Specification of the primitive
myeloid precursor pool requires signaling through Alk8 in zebrafish.
Current Biology, 16(5):506-511, 2006.
Horsfield J, Anagnostou S, Hu J, Yu Cho K, Geisler R, Lieschke G,
Crosier K, Crosier P. Cohesin-dependent regulation of runx genes.
Development 137(14):2639-2649, 2007.
Dworkin S, Heath JK, deJong-Curtain TA, Hogan BM, Lieschke GJ,
Malaterre J, Ramsay RG, Mantamadiotis T. CREB activity modulates
neural cell proliferation, midbrain-hindbrain organization and
patterning in zebrafish. Developmental Biology
307(1)127-141, 2007.
Ellett F, Kile BT, Lieschke GJ. The role of the ETS factor
erg in zebrafish vasculogenesis. Mechanisms of Development
126(3-4):220-229 2009.
De Jong-Curtain TA, Parslow AC, Trotter AJ, Hall NE, Verkade H, Tabone
T, Christie EL, Crowhurst MO, Layton JE, Shepherd IT, Nixon SJ, Parton
RG, Zon LI, Stainier DYR, Lieschke GJ, Heath JK. Abnormal
Nuclear Pore Formation Triggers Apoptosis in the Intestinal Epithelium
of elys-Deficient Zebrafish. Gastroenterology 136(3):902-911,
2009.
Pase L, Layton JE, Kloosterman WP, Carradice D, Waterhouse PM, Lieschke
GJ. miR-451 regulates zebrafish erythroid maturation in vivo via its
target gata2. Blood 113(8):1794-1804, 2009.
Berger J, Berger S, Hall TE, Lieschke GJ, Currie PD. Dystrophin-deficient
zebrafish feature aspects of Duchenne muscular dystrophy pathology.
Neuromuscular Disorders. 2010 Sep 15. [Epub ahead of print]
Ellett F, Pase L, Hayman JW, Andrianopoulos A, Lieschke GJ. mpeg1
promoter transgenes direct macrophage-lineage expression in zebrafish.
Blood in press.
Reviews
Lieschke GJ, Currie PD. Animal models of human disease –
zebrafish swim into view. Nature Reviews – Genetics
8(5):353-67, 2007.
Carradice D, Lieschke GJ. Zebrafish hematology – sushi or
science? Blood 111(7):3331-42, 2008.
Lieschke GJ, Trede NS. Fish immunology. Current
Biology 19(16):R678-82, 2009.
Ellett F, Lieschke GJ. The use of zebrafish models in
hematology research. Current Opinions in Pharmacology,
10(5):563-70, 2010.
Book
Lieschke GJ, Oates AC, Kawakami K (eds). Zebrafish: Methods
and Protocols. Humana Press, Totowa NJ USA, 2009.
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