| Biography: | Born in the United States, Nadia Rosenthal was awarded a PhD in 1981 from Harvard Medical School and trained as a postdoctoral fellow at the National Institutes of Health. After holding academic research posts in Boston at Children’s Hospital and Boston University School of Medicine she moved to the Cardiovascular Research Center at Harvard Medical School, where she directed a biomedical research laboratory at the Massachusetts General Hospital. She co-edited the definitive text Heart Development and served for a decade on the editorial staff at the New England Journal of Medicine, where she was Consultant of Molecular Medicine and editor of the Molecular Medicine series.
Professor Rosenthal’s research focuses on developmental genetics of heart and skeletal muscle, the molecular biology of ageing and the role of growth factors and stem cells in tissue regeneration. Since her 2001 arrival in Europe to become Head of the European Molecular Biology Laboratory (EMBL) Mouse Biology Unit in Rome, she has been awarded EMBO membership, and the Ferrari-Soave Prize in Cell Biology. She has served on numerous international grant review committees, advisory panels and editorial boards and coordinates several major EU consortia on mouse genetics and disease models. She delivered the 2006 Howard Hughes Holiday Lectures on Potent Biology: Stem Cells, Cloning and Regeneration. In 2005 Professor Rosenthal established a Partnership between EMBL and Imperial Collage London, where she holds a Professorship of Cardiovascular Science and co-directs of the Harefield Heart Science Centre with Sir Magdi Yacoub.
As part of a longstanding relationship with the Australian research community, Professor Rosenthal is a member of the Australia and New Zealand Society for Cell and Developmental Biology, for whom she designed the prestigious ANZSCDB Presidents Medal. She has been a faculty member of the Australian Developmental Biology Workshop and is also a Visiting Professor at The University of Western Australia. She spearheaded the election of Australia to EMBL as its first Associate Member and is the Head of Science for EMBL Australia, as well as the Founding Director of the Australian Regenerative Medicine Institute at Monash University. In 2010 she was awarded an Australia Fellowship.
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| Selected Publications: | Selected publications in last 3 years:
Mourkioti F, Kratsios P, Luedde T, Song Y-H, Delafontaine P, Adami R, Parente V, Bottinelli R Pasparakis M, Rosenthal N. Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass and promotes regeneration. J. Clin. Invest. 2006, 116: 2954-2945. PMID: 17080195
Rosenthal N, Brown S. The mouse ascending: perspectives for human-disease models. Nat Cell Biol. 2007, 9:993-9.
PMID: 17762889
Lara-Pezzi E, Winn N, Paul A, McCullagh K, Slominsky E, Santini MP, Mourkioti F, Sarathchandra P, Fukushima S, Suzuki K, Rosenthal N. A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration. J Cell Biol. 2007, 179:1205-18. PMID: 18086917
Burchfield JS, Iwasaki M, Koyanagi M, Urbich C, Rosenthal N, Zeiher AM, Dimmeler S. Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction. Circ Res. 2008 103:203-11. PMID: 18566343
Klimanskaya I, Rosenthal N, Lanza R. Derive and conquer: sourcing and differentiating stem cells for therapeutic applications. Nat Rev Drug Discov. 2008, 7:131-42. PMID: 18079756
Lara-Pezzi E, Felkin LF, Birks EJ, Sarathchandra P, Panse KD, George R, Hall J, Yacoub MH, Rosenthal N, Barton P. Expression of follistatin-related genes is altered in heart failure. Endocrinology 2008,149:5822-7.
PMID: 18617621
Dobrowolny G, Aucello M, Rizzuto E, Beccafico S, Mammucari C, Bonconpagni S, Belia S, Wannenes F, Nicoletti C, Del Prete Z, Rosenthal N, Molinaro M, Protasi F, Fanò G, Sandri M, Musarò A. Skeletal muscle is a primary target of SOD1G93A-mediated toxicity. Cell Metab. 2008, 8:425-36. PMID: 19046573
Catela C, Bilbao-Cortes D, Slonimsky E, Kratsios P, Rosenthal N, Te Welscher P. Multiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null mice. Dis Model Mech. 2009, 2:283-94. PMID: 19383940
Schofield PN, Bubela T, Weaver T, Portilla L, Brown SD, Hancock JM, Einhorn D, Tocchini-Valentini G, Hrabe de Angelis M, Rosenthal N; CASIMIR Rome Meeting participants. Post-publication sharing of data and tools. Nature. 2009, 461:171-3.
Ruffell D, Mourkioti F, Gambardella A, Kirstetter P, Lopez RG, Rosenthal N, Nerlov C. A CREB-C/EBPβ cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. Proc Natl. Acad. Sci. 2009 [Epub ahead of print]
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