Staff Directory

Title: Dr
First Name: Nicolas
Surname: Plachta
Position: Group Leader, EMBL Australia Partner Laboratory
Group: Plachta
Phone No: +61 3 9902 9612
Email Address:
Research Interests: Cell and developmental biology, biological imaging, biophysics, neurobiology, stem cells
Biography:Dr Plachta is an expert in biological imaging and embryonic development. His research provides insights into how cells and molecules interact during the early stages of life and may provide knowledge key to understanding, preventing and treating a range of diseases. Dr Plachta has recently been able to study key biological processes guiding embryonic development, such as gene expression dynamics, in intact mammalian embryos.

Before joining ARMI as the second EMBL Australia Partner Laboratory Network Group Leader, Nicolas worked at the Biological Imaging Centre of the California Institute of Technology and at the Biozentrum of the University of Basel.
Selected Publications:Fierro-Gonzalez J, White M, Silva J, Plachta N.
Cadherin-dependent filopodia control preimplantation embryo compaction.
Nature Cell Biology (2013) [2 reviews by Faculty of 1000]

Kaur G, Nefzger C, Costa M, Silva J, Fierro-Gonzalez J, Polo J, Bell T, Plachta N.
Probing transcription factor diffusion in the developing mammalian embryo with photoactivatable
fluorescence correlation spectroscopy.
Nature Communications (2013)

Plachta N, Bollenbach T, Pease S, Fraser SE, Pantazis P.
Oct4 kinetics predict cell lineage patterning in the early mammalian embryo.
Nature Cell Biology (2011) (Journal Cover) [3 reviews by Faculty of 1000]

Bissiere S, Plachta N, McAllister K, Hoyer D, Olpe HR, Grace A, Cryan JF.
The anterior cingulate cortex modulates the efficiency of amygdala dependent fear learning.
Biological Psychiatry (2008) (Journal Cover)

Nikoletopoulou V, Plachta N, Allen ND, Haubst N, Götz M, Barde Y-A.
Neurotrophin receptor-mediated death of misspecified neurons generated from embryonic stem cells
lacking Pax6.
Cell Stem Cell (2007)

Plachta N, Annaheim C, Bissiere S, Hoving S, Voshol V, Bibel M, Barde Y-A.
Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic
stem cells.
Nature Neuroscience (2007)

Plachta N, Bibel M, Tucker KL, Barde Y-A.
Developmental potential of defined neural progenitors derived from mouse embryonic stem cells.
Development (2004)

Plachta N, Traister A, Weil M.
Nitric oxide is involved in establishing the balance between cell cycle progression and cell death in the
developing neural tube.
Experimental Cell Research (2003)

Traister A, Abashidze S, Gold V, Michael E, Plachta N, Patel K, Fainsod A, Weil M.
BMP controls nitric oxide-mediated regulation of cell numbers in the neural tube.
Cell Death and Differentiation (2004)

Traister A, Abashidze S, Gold V, Plachta N, Karchovsky E, Patel K, Weil M.
Evidence that nitric oxide regulates cell cycle progression in the developing chick neuroepithelium.

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