Staff Directory

Title: Professor
First Name: Peter
Surname: Currie
Position: Deputy Director
Group: Currie
Phone No: +61 3 9902 9602
Email Address:
Research Interests: Zebrafish muscle development and evolution

A combination of genetic and embryological amenability has placed zebrafish at the forefront of attempts to understand how genes function to control vertebrate development.
The optical transparency of the zebrafish embryo provides the ability to visualise every cell in the forming embryo by simple optical inspection as well as enabling the use of a host of cell labeling and transgenic approaches to dissect embryonic development.
Furthermore, the large-scale mutagenesis of the zebrafish genome has also produced many different classes of mutations that disrupt gene function. We use the many advantages of zebrafish embryology to dissect molecular mechanisms that act to pattern the vertebrate embryo.
In particular, we are interested in how specific muscle cell types are determined within the developing embryo.
Biography:Peter D. Currie received his PhD in Drosophila genetics from Syracuse University, New York, USA. He undertook postdoctoral training in zebrafish development at the Imperial Cancer Research Fund (now Cancer Research UK) in London, UK. He has worked as an independent laboratory head at the UK Medical Research Council Human Genetics Unit in Edinburgh, UK and the Victor Chang Cardiac Research Institute in Sydney, Australia where he headed a research programme focused on skeletal muscle development and regeneration. His work is centred on understanding how the small freshwater zebrafish is able to build and regenerate both skeletal and cardiac muscle. In 2008 he was appointed Deputy Director of the Australian Regenerative Medicine Institute at Monash University in Melbourne, Australia. He is a recipient of a European Molecular Biology Organization Young Investigators Award and a Wellcome Trust International Research Fellowship and currently is a Principal Research Fellow with the National Health and Medical Research Council in Australia.
Selected Publications:Neyt C, Jagla K, Thisse C, Thisse B, Haines L, Currie PD. Evolutionary origins of vertebrate appendicular muscle. Nature 2000; 408:82-86

Hollway GE, Currie PD. Myotome meanderings. Cellular morphogenesis and the making of muscle. EMBO Reports 2003; 4:855-860

Basset DI, Bryson-Richardson RJ, Daggett DF, Gautier P, Keenan DG, Currie PD. Dystrophin is required of the formation of stable muscle attachments in the zebrafish embryo. Development 2003; 130:5851-5860

Cortes F, Daggett D, Bryson-Richardson RJ, Neyt C, Maule M, Gautier P, Hollway GE, Keenan D, Currie PD. Cadherin-mediated differential cell adhesion controls slow muscle migration in the developing zebrafish myotome. Developmental Cell 2003; 5:865-876

Daggett DF, Boyd CA, Gautier P, Bryson-Richardson RJ, Thisse C, Thisse B, Amacher SL, Currie PD. Developmentally restricted actin-regulatory molecules control morphogenetic cell movements in the zebrafish gastrula. Curr Biol 2004; 14:1632-1638

Hollway GE, Bryson-Richardson RJ, Berger S, Cole NJ, Hall TE, Currie PD. Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo. Developmental Cell 2007; 12:207-219

Lieschke GJ, Currie PD. Animal models of human disease: zebrafish swim into view. Nature Rev Genet. 2007; 8:353-367

Hall TE, Bryson-Richardson RJ, Berger S, Jacoby AS, Cole NJ, Hollway GE, Berger J, Currie PD. The zebrafish candyfloss mutant implicates extracellular matrix adhesion failure in laminin alpha2 deficient congenital muscular dystrophy. PNAS 2007; 104:7092-7097

Berger J, Berger S, Hall TE, Lieschke GJ, Currie PD. Dystrophin-deficient zebrafish feature aspects of the Duchenne muscular dystrophy pathology Neuromuscul Disord. 2010 12:826-32.

Berger J, Berger S, Jacoby AS, Wilton SD, Currie PD. Evaluation of exon-skipping strategies for Duchenne muscular dystrophy utilizing dystrophin-deficient zebrafish. J Cell Mol Med. 2011 Dec;15(12):2643-51

Cole NJ, Hall TE, Don EK, Berger S, Boisvert CA, Neyt C, Ericsson R, Joss J, Gurevich DB, Currie PD. Development and evolution of the muscles of the pelvic fin. PLoS Biol. 2011 Oct;9(10):e1001168

Goldshmit Y, Sztal T E, Jusuf P R, Hall T E, Nguyen-Chi M, and Currie P D. (2012). Fgf- Dependent Glial Cell Bridges Facilitate Spinal Cord Regeneration in Zebrafish. Journal of Neuroscience, 32:7477–7492.

Sztal TE, Sonntag C, Hall TE, Currie PD. Epistatic dissection of laminin-receptor interactions in dystrophic zebrafish muscle. Hum Mol Genet. 2012 Nov 1;21(21):4718-31.

Nguyen-Chi ME, Bryson-Richardson R, Sonntag C, Hall TE, Gibson A, Sztal T, Chua W, Schilling TF, Currie PD Morphogenesis and Cell Fate Determination within the Adaxial Cell Equivalence Group of the Zebrafish Myotome. PLoS Genet. 2012 Oct;8(10):e1003014.

Siegel AL, Gurevich DB, Currie PD. A myogenic precursor cell that could contribute to regeneration in zebrafish and its similarity to the satellite cell. FEBS J. 2013 Sep;280(17):4074-88.

Goldshmit Y, Frisca F, Pinto A R, Pébay A, Tang J K, Siegel A L Kaslin J and Currie PD. Fgf2 improves functional recovery—decreasing gliosis and increasing radial glia and neural progenitor cells after spinal cord injury. Brain and Behaviour (2014). 4:187-200.

Nguyen PD, Hollway GE, Sonntag C, Miles L, Hall TE, Berger S, Fernandez KJ, Gurevich DB, Cole NJ, Alaei S, Ramialison M, Sutherland RL, Polo JM, Lieschke GJ and Currie PD. Induction of haematopoietic stem cells by somite-derived endothelial cells controlled by meox1. (2014). Nature 512:314-8.

Goldshmit Y, Frisca, F, Kaslin J, Pinto AR, Tang JK, Pebay A, Pinkas-Kramarski R, Currie PD. Decreased anti-regenerative effects after spinal cord injury in spry4-/-mice. Neuroscience. 2015 Feb 26,287:104-12
Other Info:Funding acknowledgements
  • National Health and Medical Research Council
  • Muscular Dystrophy Association, USA
  • Australian Research Council
  • Human Frontiers Science Program
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