Staff Directory



Title: Associate Professor
First Name: Tiziano
Surname: Barberi
Position: Group Leader
Group: Barberi
Phone No: +61 3 9902 9645
Email Address: tiziano.barberi@monash.edu
Biography:Associate Professor Barberi completed doctoral degrees, at State University “La Sapienza”, Rome, Italy and at Eberhard Karls Universität Tübingen, Tübingen, Germany.  He completed his post-doctoral training at the Sloan-Kettering Institute, the research branch of Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City.

Prior to joining ARMI, Associate Professor Barberi was an Assistant Professor at Beckman Research Institute at the Beckman Research Institute of City of Hope in Duarte, California.

Dr Barberi is a leading scientist in the field of embryonic stem cell research.  His research is focused on methods to isolate stem/precursor cells originating from embryonic stem cells (ESC) that will eventually have therapeutic applications.  Using ESC as a research tool, Dr Barberi also examines fundamental questions in development, such as uncovering mechanisms of cell fate and tissue specification.  In particular, he is interested in the specification of the mesendoderm, as well as the neural crest specification during early neurulation.

At ARMI he is responsible for new ways to direct the ‘cell fate’ of embryonic stem cells – transforming them into mesoderm derivatives such as fat, bone cartilage or muscle cells or into neuroectodermal cells.

His research aims to develop new therapies to treat and prevent a range of degenerative illness.  At ARMI, Dr Barberi will continue his research into the development of striated muscle from human ESC’s, as well as his neuroscience investigations – where he is examining methods to transform stem cells into neural crest cells and retinal tissue.  In additional, Dr. Barberi has produced a number of mutant mouse ESC lines where the expression of selected transcription factors has been perturbed.
Selected Publications:Gessani S, Di Marzio P, Varano B, Borghi P, Conti L, Locardi C, Barberi T, Tritarelli E, Martucci R, Testa U, Peschle C, Belardelli F. Potentiation of TNF-α/IL-6 production and acquisition IFN-β-mediated anti-viral state after LPS treatment differentiation of human monocytes to macrophages. J Immunol. 1993;151:3758-3766.
PMID:

Testa U, Masciulli R, Tritarelli E, Pustorino R, Mariani G, Martucci R, Barberi T, Camagna A, Valtieri M, Peschle C. Transforming growth factor-β and vitamin D3 induces terminal monocytic differentiation of human leukemic cell lines. J Immunol. 1993;150:2418-2430
PMID: 8383719 

Peschle C, Gabbianelli M, Testa U, Pelosi E, Barberi T, Fossati C, Valtieri M, Leone L. c-kit ligand reactivates HbF synthesis in serum-free cultures of purified normal adult BFU-E. Blood. 1993;81:328-336.
PMID: 7678510

Testa U, Griganni F, Barberi T, Fagioli M, Masciulli R, Ferrucci PF, Seripa D, Camagna A, Alcalay M, Pelicci PG, Peschle C. PML/RARα U937 mutant and NB4 cell lines: retinoic acid restores the monocytic differentiation response to Vitamin D3. Cancer Res. 1994;54:4508-4515.
PMID: 7519122 

Gabbianelli M, Pelosi E, Montesoro E, Valtieri M, Luchetti L, Samoggia P, Vitelli L, Barberi T, Testa U, Lyman S, Peschle C. Multi-level effects of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors. Blood. 1995;86:1661-1670.
PMID: 7544638
 
Masciulli R, Testa U, Barberi T, Samoggia P, Tritarelli E, Pustorino R, Mastroberardino G, Camagna A, Peschle C. Combined vitamin D3/retinoic acid induction of human promyelocytic cell lines: enhanced phagocytic cell maturation and hybrid granulomonocytic phenotype. Cell Growth Differ. 1995;6:493-503.
PMID: 7647032

Labbaye C, Valtieri M, Barberi T, Meccia E, Masella B, Pelosi E, Condorelli GL, Testa U, Peschle C. Differential expression and functional role of GATA-2, NF-E2 and GATA-1 in normal adult hematopoiesis. J Clin Invest. 1995;95:2346-2358.
PMID: 7738198
 
Condorelli GL, Testa U, Valtieri M, Vitelli L, De Luca A, Barberi T, Montesoro E, Campisi S, Giordano A, Peschle C. Modulation of retinoblastoma gene in normal adult hematopoiesis: peak expression and functional role in advanced erythroid differentiation. Proc Natl Acad Sci USA. 1995;92:4808-4812.
PMID: 7761404

Grignani F, Testa U, Fagioli M, Barberi T, Masciulli R, Mariani G, Peschle C, Pelicci PG. Promyelocytic leukemia-specific PML-retinoic acid α receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells. Cancer Res. 1995;55:440-443.
PMID: 7529139

Testa U, Grignani F, Hassan HJ, Rogaia D, Masciulli R, Gelmetti V, Guerrero R, Macioce G, Liberatore C, Barberi T, Mariani G, Pelicci PG, Peschle C. Terminal Megakaryocytic differentiation of TF-1 cells is induced by phorbol esters and thrombopoietin and is blocked by expression of PML/RAR fusion protein. Leukemia 1998;12:563-570.
PMID: 9557615

Camagna A, Testa U, Masciulli R, Barberi T, Samoggia P, Tritarelli E, Cipollone L, Del Duca P, Dionisi S, Del Vecchio LR, Misasi G, De Martinis C, Peschle C. The synergistic effect of simultaneous addition of retinoic acid and vitamin D3 on the in vitro differentiation of human promyelocytic cell lines could be efficiently transposed in vivo. Med Hypoteses. 1998;50:253-257.
 
Rutella S, Rumi C, Lucia MB, Barberi T, Puggioni PL, Lai M, Romano A, Cauda R, Leone G. Induction of CD69 antigen on normal CD4+ and CD8+ Lymphocyte subsets and its relationship with the phenotype of responding T-cells. Cytometry. 1999;38:95-101.

Rutella S, Rumi C, Puggioni PL, Barberi T, Di Mario A, Larocca LM, Leone G.  Expression of thrombospondin receptor (CD36) on B-cell chronic lymphocytic leukaemia as an indicator of tumor cell dissemination. Haematologica. 1999;84:419-424.

Sposi NM, Cianetti L, Tritarelli E., Pelosi E, Militi S, Barberi T, Gabbianelli M, Saulle E, Kuhn L, Peschle C, Testa U. Mechanisms of differential transferrin receptor expression in normal hematopoiesis. Eur J Biochem. 2000;267:6762-6774.

Barberi T, Kliveni P, Callingasan N, Lee H, Kawamoto H, Loonam K, Perrier A, Bruses J, Rubio M, Topf N, Tabar V, Harrison N,. Beal FM, Moore MAS, Studer L. Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in Parkinsonian mice. Nature Biotech. 2003 Oct;21(10):1200-1207.

Perrier, A.L., Tabar, V., Barberi T, Rubio, M.E., Bruses, J.L., Topf, N., Harrison, N.L., Studer, L. Derivation of midbrain dopamine neurons from human embryonic stem cells Proc Natl Acad Sci USA. 2004 Aug 24;101(34):12543-8.

Barberi T, Willis LM, Socci ND and Studer L. Derivation of multipotent mesenchymal precursors from human embryonic stem Cells. PLos Medicine. 2005 Jun;2(6):e161.

Barberi T, Bradbury M, Dincer Z, Panagiotakos G, Socci ND and Studer L. Derivation of engraftable skeletal myoblasts from human embryonic stem cells. Nature Medicine. 2007 May;13(5):642-8

Lee G, Kim H, Elkabetz Y, Al Shamy G, Panagiotakos G, Barberi T, Tabar V and Studer L. Directed differentiation of human embryonic stem cells to neural crest stem cells. Nature Biotech. 2007 Dec;25(12):1468-75

Weisel KC, Moore MAS, Studer L and Barberi T. Wnt-1 overexpression leads to enhanced cardiomyogenesis and inhibition of hematopoiesis in murine embryonic stem cells. 2008 Submitted.
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