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Professor Richard Harvey - Upcoming speaker

Identification of multi-potent stem cells in the adult mammalian heart has promoted a revision of the dogma that the heart is a post-mitotic organ with limited regenerative reserve. Different stem cell populations expressing hemopoietic stem cell markers have been described. In addition, the epicardium has been flagged as a tissue with regenerative potential and cardiomyocytes are capable to re-entry into the cell cycle after cytokine induction. However, fibrosis is the preferred outcome over tissue replacement after ischemic injury, and cardiac stem and regeneration therapies are being vigorously explored. Missing pieces of the puzzle are the lineage origins of cardiac stem cells and their lineage relationships.

Our laboratory has developed a quantitative framework for characterising colony-forming cells from the adult mouse heart. Such cells (cardiac colony-forming units-fibroblast; cCFU-F) are multipotent for a variety of mesodermal lineages in vitro and in vivo, and have a gene expression and surface receptor profile resembling bone marrow (BM) mesenchymal stem/progenitor cells (MSCs). We will present our recent data on the characterisation of cCFU-F in vivo and in vitro, their origins in development, and molecules regulating their cell cycle state and stemness.

Date: Tuesday 15th November
Time: 1:00 pm — 2:00 pm
Venue: G19 Meeting room, Ground Floor, STRIP (Building 75)

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