Kaslin

Mechanisms of cellular brain plasticity

The Kaslin group focuses on understanding the molecular and cellular mechanisms that control cellular plasticity in the intact and injured vertebrate brain.

Neural stem cells and brain regeneration have been mostly been studied in vertebrates (rodents) that have very limited neurogenic potential. In contrast, we have found that zebrafish exhibit widespread adult neurogenesis and are able to regenerate parts of their CNS. These features make it possible to tackle questions in the zebrafish that are not possible in mammalian models. Our overall aim is to understand the underlying molecular and cellular mechanisms that allow/limit cellular plasticity in the vertebrate brain.

The group uses high-resolution in vivo imaging, novel genetic tools and cellular reprogramming to study how neuronal stem cells niches and tissue permissiveness arise and are being maintained. Using high-throughput sequencing we want to get a comprehensive understanding of the genetic networks that regulate cellular plasticity during homeostasis and regeneration. The elucidation of the mechanisms that govern cellular plasticity in vivo is essential for successful CNS therapies in the future.

For more information on the research undertaken by this group or for enquiries regarding positions for researchers or students please contact Dr Jan Kaslin.