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The haemopoietic system, which makes blood cells, is the archetypal
regenerative tissue, constantly supplying blood cells throughout life.
It is capable of large bursts of replenishment following injuries such
as chemotherapy. White blood cells (leukocytes) are a key cellular
player in host defense and as effectors of inflammation. Their function
plays a major role in determining the balance between ongoing tissue
injury, scarring, healing and regeneration.
The Lieschke group use zebrafish as the model organism for studying
blood development and function. The team was one of the first groups in
the world to take advantage of the genetic flexibility and imaging
capacity of zebrafish for white blood cell research. Mutants with
faulty blood cell development provide handles on genes regulating the
haemopoietic system. Several mutants have proven useful for studying
the role of particular leukocytes in inflammation and healing. The
Group has developed an infection model to stress leukocyte function.
For more information on the research undertaken by this group or for
enquiries regarding positions for researchers or students please
contact Graham Lieschke.
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Click here to download an overview of the Lieschke Group.
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