Patterning of the vertebrate skeleton
The McGlinn Group uses the developing limb bud and axial skeleton to
understand genetic hierarchies governing patterning mechanisms.
The reiterative use of key signaling pathways across multiple organs has
meant that the limb, with its advantages of ease of manipulation and
lack of requirement for embryonic survival, has provided fundamental
contributions to our understanding of broader developmental processes.
More recently, it has become clear that a comprehensive understanding of
these processes requires integration of all levels of gene regulation,
including both protein-coding and non-protein coding mechanisms.
For this reason, we have pioneered a novel approach to investigate the
role of microRNAs in development.
We aim to build a more complete molecular road-map of how the size,
shape and number of bones form within the early vertebrate embryo.
For more information on the research undertaken by this group or for
enquiries regarding positions for researchers or students please
contact Edwina McGlinn
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Click here to download an overview of the McGlinn Group
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