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We are interested in understanding the cellular and molecular mechanisms regulating myogenic differentiation, growth and repair using chick and mouse as models and high-end imaging technologies as investigation tools.
Ongoing research projects include:
- The analysis of early muscle differentiation and characterising the gene networks implicated in
- Muscle fusion
- The quiescence or proliferation of satellite cells.
Sieiro D, Véron N, Marcelle C.
The chicken embryo as an efficient model to test the function of muscle fusion genes in amniotes.
PLoS One. 2017; 12(5): e0177681 2017 May 16. doi: 10.1371/journal.pone.0177681.
Rios AC, Serralbo O, Salgado D, Marcelle C.
Neural crest regulates myogenesis through the transient activation of Notch.
Nature. 2011 May 26;473(7348):532-5. doi: 10.1038/nature09970. Epub 2011 May 15.
Gros J, Serralbo O, Marcelle C.
Wnt11 acts as a directional cue to organize the elongation of early muscle fibers.
Nature. 2009 Jan 29;457(7229):589-93. doi: 10.1038/nature07564. Epub 2008 Nov 5.
Manceau M, Savage K, Gros J, Thomé V, McPherron A, Paterson B, Marcelle C.
Myostatin promotes the terminal differentiation of embryonic muscle progenitors.
Genes Dev. 2008 Mar 1;22(5):668-81. doi: 10.1101/gad.454408.
Gros J, Manceau M, Thomé V, Marcelle C.
A common somitic origin for embryonic muscle progenitors and satellite cells.
Nature. 2005 Jun 16;435(7044):954-8. Epub 2005 Apr 20.
Gros J, Scaal M, Marcelle C.
A two step mechanism for myotome formation in chick.
Dev Cell. 2004 Jun;6(6):875-82.
Garcia-Castro M, Marcelle C, Bronner-Fraser M.
Ectodermal wnt function as a neural crest inducer.
Science. 2002 Aug 2;297(5582):848-51.