Completed in 2017, the Monash Transgenic Quail Facility (MTQF) at ARMI is unique – producing and maintaining transgenic Japanese quail lines for use in scientific research.

Avian models are used to investigate skeletal muscle regeneration and are considered to be superior animal models compared to mice in this specific area. The skeletal muscle system of birds is evolutionarily close to humans, and the embryo is more accessible compared to mammal models, due to its development in a shell. As such, genetic manipulation in quail is faster and cheaper.

Advantages of using these birds include easy access to the embryo and six weeks generation. Because of this short generation time, the Japanese quail is an ideal model for genetic research.  It is also suitable for pilot experiments in the poultry industry.

The MTQF has the unique capability and expertise to generate on-demand transgenic quails using the Tol2 genome integration technique or gene editing knock-out using CRISPR/Cas9 technology.  The MTQF the first quail facility in the world to achieve this capability.

In addition to providing transgenic quails, the facility is also able to provide wild-type and genetically modified quails and provide shipment of wild-type and quail eggs in Australia and overseas. The facility also can deliver training in how to use quail embryos as a research tool and standard imaging techniques.

The MTQF, an approved Physical Containment level 2 (PC2), QAP5.1 quarantine certified facility, is open for researchers and industry to use. To find out more information, contact Olivier Serralbo, Facility Manager at olivier.serralbo@monash.edu.

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