The Cooper-White group is passionate about bridging the biological and engineering sciences to develop novel solutions to tissue generation and repair. Through our understanding of adult and pluripotent stem cell biology and physiology, our lab aims to exploit our expertise in biomaterial synthesis, fabrication and biomimicry to manipulate stem cell fate choices to drive regeneration in a targeted and efficient manner.

Research

The ARMI affiliated Cooper-White group is focused on the development of novel microfabricated devices, artificial cell culture substrates, directive bionanomaterials, and injectable tissue-integrating hydrogels for applications in stem cell culture, gene therapy, regenerative medicine and tissue engineering. 

  • Mesenchymal stem cells and therapeutic benefit: Importance of cell-cell communication and paracrine signaling
  • “Remodeling” functionalised hydrogels for directed tissue genesis
  • Mechanotransduction and reprogramming to pluripotency
  • High Throughput Biomaterials Discovery for TE and RM Applications
  • Tissue- and Organ-on-a-chip for HTP Screening and Discovery
  • Direct Reprogramming for In Vivo Cardiac Tissue Regeneration through Targeted Gene Therapy

Featured Publications

More Publications

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Title
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Joensuu M, Martínez-Mármol R, Padmanabhan P, Glass NR, Durisic N, Pelekanos M, Mollazade M, Balistreri G, Amor R, Cooper-White JJ, Goodhill GJ, Meunier FA.

Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules.

Nat Protoc. 2017 Dec;12(12):2590-2622. doi: 10.1038/nprot.2017.116. Epub 2017 Nov 30.

Trott J, Tan EK, Ong S, Titmarsh DM, Denil SLIJ, Giam M, Wong CK, Wang J, Shboul M, Eio M, Cooper-White JJ, Cool SM, Rancati G, Stanton LW, Reversade B, Dunn NR.

 Long-term culture of self-renewing pancreatic progenitors derived from human pluripotent stem cells.

Stem Cell Reports. 2017 Jun 6;8(6):1675-1688. doi: 10.1016/j.stemcr.2017.05.019.

Tailoring biomaterial scaffolds for osteochondral repair.

Int J Pharm. 2017 May 25;523(2):476-489. doi: 10.1016/j.ijpharm.2016.10.035. Epub 2016 Oct 19.

Lim KZ, Daly CD, Ghosh P, Jenkin G, Oehme D, Cooper-White JJ, Naidoo T, Goldschlager T.

Ovine Lumbar Intervertebral Disc Degeneration Model Utilizing a Lateral Retroperitoneal Drill Bit Injury.

J Vis Exp. 2017 May 25;(123). doi: 10.3791/55753.

The focal adhesion targeting domain of p130Cas confers a mechanosensing function.

J Cell Sci. 2017 Apr 1;130(7):1263-1273. doi: 10.1242/jcs.192930. Epub 2017 Feb 21.

Cosson S, Danial M, Saint-Amans JR, Cooper-White JJ.

Accelerated combinatorial high throughput star polymer synthesis via a rapid one-pot sequential aqueous RAFT (rosa-RAFT) polymerization scheme.

Macromol Rapid Commun. 2017 Apr;38(8). doi: 10.1002/marc.201600780. Epub 2017 Feb 21.

Titmarsh DM, Tan CLL, Glass NR, Nurcombe V, Cooper-White JJ, Cool SM.

Microfluidic screening reveals heparan sulfate enhances human mesenchymal stem cell growth by modulating fibroblast growth factor-2 transport.

Stem Cells Transl Med. 2017 Apr;6(4):1178-1190. doi: 10.1002/sctm.16-0343. Epub 2017 Feb 16.

Camarero-Espinosa S, Stefani I, Cooper-White JJ.

Hierarchical “as-electrospun” selfassembled fibrous scaffolds deconvolute impacts of chemically defined extracellular matrix- and cell adhesion-type interactions on stem cell haptokinesis.

ACS Macro Letters 2017;6(12):1420–1425. doi:10.1021/acsmacrolett.7b00834.

Cork J, Whittaker AK, Cooper-White JJ, Grondahl L.

Electrospinning and mechanical properties of P(TMC-co-LLA) elastomers.

Journal of Materials Chemistry B 2017;5(12):2263–2272. doi: 10.1039/c7tb00137a.

Maisonneuve BG, Roux DC, Thorn P, Cooper-White JJ.

Effects of synthetic biomacromolecule addition on the flow behavior of concentrated mesenchymal cell suspensions.

Biomacromolecules. 2015 Jan 12;16(1):275-83. doi: 10.1021/bm501481y. Epub 2014 Dec 12.

Li H, Frith J, Cooper-White JJ.

Modulation of stem cell adhesion and morphology via facile control over surface presentation of cell adhesion molecules.

Biomacromolecules. 2014 Jan 13;15(1):43-52. doi: 10.1021/bm4012562. Epub 2013 Dec 3.

Frith JE, Menzies DJ, Cameron AR, Ghosh P, Whitehead DL, Gronthos S, Zannettino AC, Cooper-White JJ.

Effects of bound versus soluble pentosan polysulphate in PEG/HA-based hydrogels tailored for intervertebral disc regeneration.

Biomaterials. 2014 Jan;35(4):1150-62. doi: 10.1016/j.biomaterials.2013.10.056. Epub 2013 Nov 8.

Frith JE, Titmarsh DM, Padmanabhan H, Cooper-White JJ.
Microbioreactor array screening of Wnt modulators and microenvironmental factors in osteogenic differentiation of mesenchymal progenitor cells.

PLoS One. 2013 Dec 23;8(12):e82931. doi: 10.1371/journal.pone.0082931. eCollection 2013.