Microtubules are highly dynamic cytoskeletal filaments regulating fundamental processes including cell division, migration and differentiation. The Zenker group seeks to understand how a cell’s structure and function is regulated by the continuous re-organization of the microtubule network. Live imaging is used to discover the spatio-temporal accuracy of the microtubule dynamics in animal models of developmental and stem cell biology.

  • Unravelling microtubule dynamics at the single cell level using live imaging.

Featured Publications

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White MD, Zenker J, Bissiere S, Plachta N.

Instructions for Assembling the Early Mammalian Embryo.

Dev Cell. 2018 Jun 18;45(6):667-679. doi: 10.1016/j.devcel.2018.05.013.

Zhao ZW*, White MD*, Zenker J*, Alvarez YD, Bissiere S, Plachta N.

Quantifying transcription factor-DNA binding in single cells in vivo with photoactivatable fluorescence correlation spectroscopy.

Nat Protoc. 2017 Jul;12(7):1458-1471. doi: 10.1038/nprot.2017.051. Epub 2017 Jun 29.

Stettner M, Zenker J, Klingler F, Szepanowski F, Hartung HP, Mausberg AK, Kleinschnitz C, Chrast R, Kieseier BC.

The role of Peripheral Myelin Protein 2 in Remyelination.

Cell Mol Neurobiol. 2018 Mar;38(2):487-496. doi: 10.1007/s10571-017-0494-0. Epub 2017 Apr 26.

White MD, Zenker J, Bissiere S, Plachta N.

How cells change shape and position in the early mouse embryo.

Current Opinion in Cell Biology 2017 Feb;44:7-13. doi: 10.1016/j.ceb.2016.11.002. Epub 2016 Dec 26.

Barneo-Muñoz M, Juárez P, Civera-Tregón A, Yndriago L, Pla-Martin D, Zenker J, Cuevas-Martín C, Estela A, Sánchez-Aragó M, Forteza-Vila J, Cuezva JM, Chrast R, Palau F.

Lack of GDAP1 induces neuronal calcium and mitochondrial defects in a knockout mouse model of charcot-marie-tooth neuropathy.

PLoS Genet. 2015 Apr 10;11(4):e1005115. doi: 10.1371/journal.pgen.1005115. eCollection 2015 Apr.

Zenker J, Stettner M, Ruskamo S, Domènech-Estévez E, Baloui H, Médard JJ, Verheijen MH, Brouwers JF, Kursula P, Kieseier BC, Chrast R.

A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells.

Glia. 2014 Sep;62(9):1502-12. doi: 10.1002/glia.22696. Epub 2014 May 21.

Ngo L, Haas M, Qu Z, Li SS, Zenker J, Teng KS, Gunnersen JM, Breuss M, Habgood M, Keays DA, Heng JI.

TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons.

Hum Mol Genet. 2014 Oct 1;23(19):5147-58. doi: 10.1093/hmg/ddu238. Epub 2014 May 15.

Zenker J, Ziegler D, Chrast R.

Novel pathogenic pathways in diabetic neuropathy.

Trends Neurosci. 2013 Aug;36(8):439-49. doi: 10.1016/j.tins.2013.04.008. Epub 2013 May 29.

Azzedine H, Zavadakova P, Planté-Bordeneuve V, Vaz Pato M, Pinto N, Bartesaghi L, Zenker J, Poirot O, Bernard-Marissal N, Arnaud Gouttenoire E, Cartoni R, Title A, Venturini G, Médard JJ, Makowski E, Schöls L, Claeys KG, Stendel C, Roos A, Weis J, Dubourg O, Leal Loureiro J, Stevanin G, Said G, Amato A, Baraban J, LeGuern E, Senderek J, Rivolta C, Chrast R.

PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease.

Hum Mol Genet. 2013 Oct 15;22(20):4224-32. doi: 10.1093/hmg/ddt274. Epub 2013 Jun 17.

Zenker J, Poirot O, de Preux Charles AS, Arnaud E, Médard JJ, Lacroix C, Kuntzer T, Chrast R.

Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus.

J Neurosci. 2012 May 30;32(22):7493-8. doi: 10.1523/JNEUROSCI.0719-12.2012.

Stendel C, Roos A, Kleine H, Arnaud E, Ozçelik M, Sidiropoulos PN, Zenker J, Schüpfer F, Lehmann U, Sobota RM, Litchfield DW, Lüscher B, Chrast R, Suter U, Senderek J.

SH3TC2, a protein mutant in Charcot-Marie-Tooth neuropathy, links peripheral nerve myelination to endosomal recycling.

Brain. 2010 Aug;133(Pt 8):2462-74. doi: 10.1093/brain/awq168.

de Preux Charles AS, Verdier V, Zenker J, Peter B, Médard JJ, Kuntzer T, Beckmann JS, Bergmann S, Chrast R.

Global transcriptional programs in peripheral nerve endoneurium and DRG are resistant to the onset of type 1 diabetic neuropathy in Ins2 mice.

PLoS One. 2010 May 26;5(5):e10832. doi: 10.1371/journal.pone.0010832.

Arnaud E, Zenker J, de Preux Charles AS, Stendel C, Roos A, Médard JJ, Tricaud N, Kleine H, Luscher B, Weis J, Suter U, Senderek J, Chrast R.

SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17528-33. doi: 10.1073/pnas.0905523106. Epub 2009 Sep 29.