Professor Nagy established a satellite lab at ARMI in 2015 to more seamlessly integrate his research efforts with collaborators at Monash and in Australia. Many research themes extend across both Canadian and Australian labs. To learn more about the Toronto-based Nagy group and research interests, see  At ARMI, the Nagy lab is working to develop novel cell therapies for brain injury, stroke and multiple sclerosis (MS).

Published In

Guo L, Karoubi G, Duchesneau P, Shutova MV, Sung HK, Tonge P, Bear C, Rogers I, Nagy A, Waddell TK.

Generation of induced progenitor-like cells from mature epithelial cells using interrupted reprogramming.

Stem Cell Reports. 2017 Dec 12;9(6):1780-1795. doi: 10.1016/j.stemcr.2017.10.022. Epub 2017 Nov 30.

Behringer R, Gertsenstein M, Nagy KV, Nagy A.

Testing serum batches for mouse embryonic stem cell culture.

Cold Spring Harb Protoc. 2017 Dec 1;2017(12):pdb.prot092411. doi: 10.1101/pdb.prot092411.

Behringer R, Gertsenstein M, Nagy KV, Nagy A.

Preparation of DNA from embryonic stem cells or other cultured cells.

Cold Spring Harb Protoc. 2017 Dec 1;2017(12):pdb.prot092718. doi: 10.1101/pdb.prot092718.

Kim KH, Kim YH, Son JE, Lee JH, Kim S, Choe MS, Moon JH, Zhong J, Fu K, Lenglin F, Yoo JA, Bilan PJ, Klip A, Nagy A, Kim JR, Park JG, Hussein SM, Doh KO, Hui CC, Sung HK.

Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage.

Cell Res. 2017 Nov;27(11):1309-1326. doi: 10.1038/cr.2017.126. Epub 2017 Oct 17.


Integrating piggyBac transposon transgenes into mouse fibroblasts by electroporation.

Behringer R, Gertsenstein M, Nagy KV, Nagy A.

Reprogramming mouse fibroblasts with piggyBac transposons.

Cold Spring Harb Protoc. 2017 Oct 3;2017(10):pdb.prot092627. doi: 10.1101/pdb.prot092627.

Andrews PW, Ben-David U, Benvenisty N, Coffey P, Eggan K, Knowles BB, Nagy A, Pera M, Reubinoff B, Rugg-Gunn PJ, Stacey GN.

Assessing the safety of human pluripotent stem cells and their derivatives for clinical applications.

Stem Cell Reports. 2017 Jul 11;9(1):1-4. doi: 10.1016/j.stemcr.2017.05.029.

Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, Lee BJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, Shong M, Koh GY.

VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis.

EMBO Mol Med. 2017 Jun;9(6):750-769. doi: 10.15252/emmm.201607341.

Shipment of live preimplantation-stage mouse embryos.

Cold Spring Harb Protoc. 2017 May 1;2017(5):pdb.prot092742. doi: 10.1101/pdb.prot092742.

Bertin E, Piccoli M, Franzin C, Nagy A, Mileikovsky M, De Coppi P, Pozzobon M.

The production of pluripotent stem cells from mouse amniotic fluid cells using a transposon system.

J Vis Exp. 2017 Feb 28;(120). doi: 10.3791/54598.

Lindqvist J, Torvaldson E, Gullmets J, Karvonen H, Nagy A, Taimen P, Eriksson JE.

Nestin contributes to skeletal muscle homeostasis and regeneration.

Journal of Cell Science 2017;130(17):2833–2842. doi: 10.1242/jcs.202226.

Faiz M, Sachewsky N, Gascón S, Bang KW, Morshead CM, Nagy A.

Adult Neural Stem Cells from the Subventricular Zone Give Rise to Reactive Astrocytes in the Cortex after Stroke.

Cell Stem Cell 2015 Nov 5;17:1-11. doi: PMID: 26456685.

Hussein SM, Batada NN, Vuoristo S, Ching RW, Autio R, Närvä E, Ng S, Sourour M, Hämäläinen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brüstle O, Bazett-Jones DP, Alitalo K, Lahesmaa R, Nagy A, Otonkoski T.

Copy number variation and selection during reprogramming to pluripotency.

Nature. 2011 Mar 3;471(7336):58-62. doi: 10.1038/nature09871. PMID: 21368824, 475 citations.

Samavarchi-Tehrani P, Golipour A, David L, Sung HK, Beyer TA, Datti A, Woltjen K, Nagy A, Wrana JL.

Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming.

Cell Stem Cell. 2010 Jul 2;7(1):64-77. doi: 10.1016/j.stem.2010.04.015. Epub 2010 Jun 17. PMID: 20621051, 396 citations.

Woltjen K, Michael IP, Mohseni P, Desai R, Mileikovsky M, Hämäläinen R, Cowling R, Wang W, Liu P, Gertsenstein M, Kaji K, Sung HK, Nagy A.

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells.

Nature. 2009 Apr 9;458(7239):766-70. doi: 10.1038/nature07863. Epub 2009 Mar 1. PMID: 19252478, 923 citations.

International Stem Cell Initiative, Adewumi O, Aflatoonian B, Ahrlund-Richter L, Amit M, Andrews PW, Beighton G, Bello PA, Benvenisty N, Berry LS, Bevan S, Blum B, Brooking J, Chen KG, Choo AB, Churchill GA, Corbel M, Damjanov I, Draper JS, Dvorak P, Emanuelsson K, Fleck RA, Ford A, Gertow K, Gertsenstein M, Gokhale PJ, Hamilton RS, Hampl A, Healy LE, Hovatta O, Hyllner J, Imreh MP, Itskovitz-Eldor J, Jackson J, Johnson JL, Jones M, Kee K, King BL, Knowles BB, Lako M, Lebrin F, Mallon BS, Manning D, Mayshar Y, McKay RD, Michalska AE, Mikkola M, Mileikovsky M, Minger SL, Moore HD, Mummery CL, Nagy A, Nakatsuji N, O'Brien CM, Oh SK, Olsson C, Otonkoski T, Park KY, Passier R, Patel H, Patel M, Pedersen R, Pera MF, Piekarczyk MS, Pera RA, Reubinoff BE, Robins AJ, Rossant J, Rugg-Gunn P, Schulz TC, Semb H, Sherrer ES, Siemen H, Stacey GN, Stojkovic M, Suemori H, Szatkiewicz J, Turetsky T, Tuuri T, van den Brink S, Vintersten K, Vuoristo S, Ward D, Weaver TA, Young LA, Zhang W.

Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.

Nat Biotechnol. 2007 Jul;25(7):803-16. Epub 2007 Jun 17. PMID: 17572666, 566 citations.

Nagy A, Gertsensten M, Vintersten K, Behringer R.

Manipulating the Mouse Embryo: A Laboratory manual.

3rd edition, Cold Spring Harbor Press, Cold Spring Harbor, New York, >9200 copies sold. (2003)

Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A.

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. citations

Nature. 1996 Apr 4;380(6573):435-9. PMID: 8602241, 2788 citations.

Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC.

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8424-8. PMID: 8378314, 1652 citations.