Staff Events
Associate Professor Gonçalo Castelo-Branco

Single-cell transcriptomics and epigenomics reveal diseasespecific states of oligodendroglia in multiple sclerosis

A/Prof Gonçalo Castelo-Branco
Karolinska Institutet


Bio

Dr Gonçalo Castelo-Branco is an Associate Professor of Neurobiology at the Department of Medical Biochemistry and Biophysics at Karolinska Institutet, Stockholm, Sweden. Dr. Castelo-Branco received his PhD in Medical Biochemistry in 2005, working on development of dopaminergic neurons and neural stem differentiation. He completed post-doctoral fellowships first at the Karolinska Institutet and then at the University of Cambridge, United Kingdom, working in neural and pluripotent stem cells and chromatin. Dr. Castelo-Branco started his research group in 2012, focusing on the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage. The main focus of Dr. CasteloBranco's research group is to investigate how distinct epigenetic states within the oligodendrocyte lineage are established, by identifying key transcription factors, chromatin modifying complexes and non-coding RNAs that are involved in epigenetic transitions, using technologies such as RNA-Seq (single-cell and bulk), quantitative proteomics and epigenomics, among others. The long term aim of his research group to design epigenetic based-therapies to induce regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis.