The Marcelle group is interested in understanding how unspecialised mesodermal cells in the embryo become specialised functional skeletal muscle cells. The group addresses those questions using chick and mouse embryos as the model. The researchers study the cellular and molecular mechanisms regulating this cell specialisation using high-end in vivo electroporation and imaging.


The group’s two main aims are to characterise the signalling pathways regulating the initiation of muscle cell formation (myogenesis) in the early embryo and to identify the gene networks underlying muscle cell fusion, which leads to the formation of multinucleated muscle fibres.


Group Members

Research Themes

  • How the process of morphogenesis of skeletal muscles is regulated at a cellular and molecular level
  • Identifying putative candidate genes important in fusion
  • Defining a core gene network governing “stem-cellness” in muscle.

More Publications

AuthorsTitlePublished In

Sieiro D, Véron N, Marcelle C.

The chicken embryo as an efficient model to test the function of muscle fusion genes in amniotes.

PLoS One. 2017; 12(5): e0177681 2017 May 16. doi:  10.1371/journal.pone.0177681.

Morin V, Véron N, Marcelle C.

CRISPR/Cas9 in the Chicken Embryo.

Methods Mol Biol. 2017;1650:113-123. doi: 10.1007/978-1-4939-7216-6_7.

Sieiro D, Rios AC, Hirst CE, Marcelle C.

Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis.

Elife. 2016 May 24;5. pii: e14847. doi: 10.7554/eLife.14847.

Hirst CE, Marcelle C.

The avian embryo as a model system for skeletal myogenesis.

Results Probl Cell Differ. 2015;56:99-122. doi: 10.1007/978-3-662-44608-9_5.

Sieiro-Mosti D, De La Celle M, Pele M, Marcelle C.

A dynamic analysis of muscle fusion in the chick embryo.

Development. 2014 Sep;141(18):3605-11. doi: 10.1242/dev.114546.

Serralbo O, Marcelle C.

Migrating cells mediate long-range WNT signaling.

Development. 2014 May;141(10):2057-63. doi: 10.1242/dev.107656.

Ruparelia AA, Simkin JE, Salgado D, Newgreen DF, Martins GG, Bryson-Richardson RJ.

The quail anatomy portal.

Database (Oxford). 2014 Apr 7;2014(0):bau028. doi: 10.1093/database/bau028. Print 2014.

Figeac N, Serralbo O, Marcelle C, PS Zammit.

ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells.

Dev Biol. 2014 Feb 1;386(1):135-51. doi: 10.1016/j.ydbio.2013.11.017. Epub 2013 Nov 22.

Bladen CL, Thompson R, Jackson JM, Garland C, Wegel C, Ambrosini A, Pisano P, Walter MC, Schreiber O, Lusakowska A, Jedrzejowska M, Kostera-Pruszczyk A, van der Pol L, Wadman RI, Gredal O, Karaduman A, Topaloglu H, Yilmaz O, Matyushenko V, Rasic VM, Kosac A, Karcagi V, Garami M, Herczegfalvi A, Monges S, Moresco A, Chertkoff L, Chamova T, Guergueltcheva V, Butoianu N, Craiu D, Korngut L, Campbell C, Haberlova J, Strenkova J, Alejandro M, Jimenez A, Ortiz GG, Enriquez GV, Rodrigues M, Roxburgh R, Dawkins H, Youngs L, Lahdetie J, Angelkova N, Saugier-Veber P, Cuisset JM, Bloetzer C, Jeannet PY, Klein A, Nascimento A, Tizzano E, Salgado D, Mercuri E, Sejersen T, Kirschner J, Rafferty K, Straub V, Bushby K, Verschuuren J, Beroud C, Lochmüller H.

Mapping the differences in care for 5,000 spinal muscular atrophy patients, a survey of 24 national registries in North America, Australasia and Europe.

J Neurol. 2014 Jan;261(1):152-63. doi: 10.1007/s00415-013-7154-1. Epub 2013 Oct 27.

Rios AC, Serralbo O, Salgado D, Marcelle C.

Neural crest regulates myogenesis through the transient activation of Notch.

Nature. 2011 May 26;473(7348):532-5. doi: 10.1038/nature09970. Epub 2011 May 15.

Relaix F, Marcelle C.

Muscle stem cells.

Current Opinion in Cell Biology 2009, 21:748–753. doi: 10.1016/

Rios AC, Marcelle C.

Head muscles: aliens who came in from the cold?

Dev Cell. 2009 Jun;16(6):779-80. doi: 10.1016/j.devcel.2009.06.004.

Gros J, Serralbo O, Marcelle C.

Wnt11 acts as a directional cue to organize the elongation of early muscle fibers.

Nature. 2009 Jan 29;457(7229):589-93. doi: 10.1038/nature07564. Epub 2008 Nov 5.

Manceau M, Savage K, Gros J, Thomé V, McPherron A, Paterson B, Marcelle C.

Myostatin promotes the terminal differentiation of embryonic muscle progenitors.

Genes Dev. 2008 Mar 1;22(5):668-81. doi: 10.1101/gad.454408.

Gros J, Manceau M, Thomé V, Marcelle C.

A common somitic origin for embryonic muscle progenitors and satellite cells.

Nature. 2005 Jun 16;435(7044):954-8. doi: 10.1038/nature03572 Epub 2005 Apr 20.

Gros J, Scaal M, Marcelle C.

A two step mechanism for myotome formation in chick.

Dev Cell. 2004 Jun;6(6):875-82. doi: 10.1016/j.devcel.2004.05.006

Garcia-Castro M, Marcelle C, Bronner-Fraser M.

Ectodermal wnt function as a neural crest inducer.

Science. 2002 Aug 2;297(5582):848-51.