The del Monte-Nieto group is interested in the study of the molecular mechanisms and developmental processes orchestrating normal heart development in embryos by integrating all the cellular and non-cellular components involved.
The lab aims to apply multidisciplinary approaches including mathematical modeling and bioengineering to developmental biology studies in order to generate in silico and in vitro models to confirm our biological results and formulate new hypothesis.
The knowledge generated from these basic developmental biology models will allow us to generate new insights to better understand the processes responsible for the onset of congenital cardiac disease and to identify potential targets to design efficient genetic screening for patients and therapies to ameliorate disease sequelae including improving the regeneration capacity of the heart after infarction.
Furthermore, these bioengineered in vitro models will help us to develop improved and more efficient engineered tissues for transplantation and organ-on-a-chip devises for personalized drug screening.
Funding acknowledgements